Antecedents: The Dominican Republic, located in a tropical zone, is frequently hit by epidemias of Dengue and is at the present going through one.
Matherials and methods: It is a retrospective study about the data in the Pediatric Service of Dr. Luis E. Aybar Hospital in Santo Domingo, Dominican Republic, during the Dengue epidemia in the trimester August-September-October 2006, similar to the one affecting the country at the present time.
Results: A total of 225 patients were dealt with, 152 (67.6%) were managed ambulatory and 73 (32.4%) were admitted. The average age of the patients was 9.7 years, ranging from 9 months to 15 years. In relation to sex, 123 (54.8%) were males and 102 (45.2%) were females. Regarding race, 90% of them were mestizos and 10% belong to other races. Of the patients admitted 48 (65.8%) had a relative oscilation of the hematocrit of 20% or more and 10 patients (13.7%) had a drop of the PAM of 10 mm Hg and it was necessary to open the IV fluid freely. When the hematocrit returned normal 5 patients (6.8%) presented signs of left ventricular failure and it was necessary to digitalized them. Mortality in this group of patients was 0 %.
Conclusions: the history of 225 patients with dengue at the Dr. Luis E. Aybar Hospital in Santo Domingo, Dominican Republic, in 2006 is reported. It is highlighted that 67.6% of them were treated as outpatients and 32.4% were hospitalized. Mortality was 0%.
Antecedents: The Dominican Republic, located in a tropical zone, is frequently hit by epidemias of Dengue and is at the present going through one.
Matherials and methods: It is a retrospective study about the data in the Pediatric Service of Dr. Luis E. Aybar Hospital in Santo Domingo, Dominican Republic, during the Dengue epidemia in the trimester August-September-October 2006, similar to the one affecting the country at the present time.
Results: A total of 225 patients were dealt with, 152 (67.6%) were managed ambulatory and 73 (32.4%) were admitted. The average age of the patients was 9.7 years, ranging from 9 months to 15 years. In relation to sex, 123 (54.8%) were males and 102 (45.2%) were females. Regarding race, 90% of them were mestizos and 10% belong to other races. Of the patients admitted 48 (65.8%) had a relative oscilation of the hematocrit of 20% or more and 10 patients (13.7%) had a drop of the PAM of 10 mm Hg and it was necessary to open the IV fluid freely. When the hematocrit returned normal 5 patients (6.8%) presented signs of left ventricular failure and it was necessary to digitalized them. Mortality in this group of patients was 0 %.
Conclusions: the history of 225 patients with dengue at the Dr. Luis E. Aybar Hospital in Santo Domingo, Dominican Republic, in 2006 is reported. It is highlighted that 67.6% of them were treated as outpatients and 32.4% were hospitalized. Mortality was 0%.
Halstead SB. The pathogenesis of Dengue. Molecular epidemiology in infectious disease. American Journal of Epidemiology. 1981;114(5):632-48.
Halstead SB. Dengue hemorraghic fever. A public health problem and a field for research. Bull WHO. 1980;58:1.
Halstead SB. Pathogenesis of Dengue. Challengue to molecular biology. Science. 1988;239:476
Feris JM, Mercedes M. Conocimiento médico del Dengue Hemorrágico en la República Dominicana. Acta Medica Dominicana. 1988;10(2):60-1.
Riveron-Corteguera y colaboradores. Fiebre hemorrágica del Dengue en Cuba. Estudio de 783 pacientes egresados del Hospital Pediátrico Docente de Centro Habana, junio-septiembre 1981. Acta Médica Dominicana. 1984;6 (1):184-94.
Guzmán MG, Alvárez M, Halstead SB. Secondary infection as a risk factor for Dengue hemorraghic fever/Dengue shock syndrome: an historical perspective and role of antibody-dependent enhancement of infection. Arch Virol. 2013;2158:1445-59.
World Health Organization. Dengue and severe Dengue. April 2019. Disponible en: www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue
Escarfuller C, Rodríguez Grullón JM, Espaillat Arias R, Beltré V. Diagnóstico temprano de Leptospirosis. Archivos Médicos Dominicanos. 2017;1(1):7-13.
Feliz E. (miércoles 8 de nov 2023). Rueda de prensa, Televisión Nacional.
World Health Organization. Dengue vaccine research. Dec 2017. Disponible en: http://www.who.int/inmunization/research/develop6ment/dengue_vaccines/en/
Sáez-Llorens X, Tricou V, Yu D, Rivera L, Jimeno J, Villarreal AC, Dato E, Mazara S, Vargas M, Brose M, Rauscher M, Tuboi S, Borkowski A, Wallace D. Immunogenicity and safety of one versus two doses of tetravalent dengue vaccine in healthy children aged 2-17 years in Asia and Latin America: 18-month interim data from a phase 2, randomised, placebo-controlled study. Lancet Infect Dis. 2018;18(2):162-70. doi: 10.1016/S1473-3099(17)30632-1.
Capeding MR, Tran NH, Hadinegoro SR, Ismail HI, Chotpitayasunondh T, Chua MN, Luong CQ, Rusmil K, Wirawan DN, Nallusamy R, Pitisuttithum P, Thisyakorn U, Yoon IK, van der Vliet D, Langevin E, Laot T, Hutagalung Y, Frago C, Boaz M, Wartel TA, Tornieporth NG, Saville M, Bouckenooghe A; CYD14 Study Group. Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia: a phase 3, randomised, observer-masked, placebo-controlled trial. Lancet. 2014;384(9951):1358-65. doi: 10.1016/S0140-6736(14)61060-6.
Guzman MG, Halstead SB, Artsob H, Buchy P, Farrar J, Gubler DJ, Hunsperger E, Kroeger A, Margolis HS, Martínez E, Nathan MB, Pelegrino JL, Simmons C, Yoksan S, Peeling RW. Dengue: a continuing global threat. Nat Rev Microbiol. 2010;8(12 Suppl):S7-16. doi: 10.1038/nrmicro2460.
Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, Drake JM, Brownstein JS, Hoen AG, Sankoh O, Myers MF, George DB, Jaenisch T, Wint GR, Simmons CP, Scott TW, Farrar JJ, Hay SI. The global distribution and burden of dengue. Nature. 2013;496(7446):504-7. doi: 10.1038/nature12060.
Sridhar S, Luedtke A, Langevin E, Zhu M, Bonaparte M, Machabert T, Savarino S, Zambrano B, Moureau A, Khromava A, Moodie Z, Westling T, Mascareñas C, Frago C, Cortés M, Chansinghakul D, Noriega F, Bouckenooghe A, Chen J, Ng SP, Gilbert PB, Gurunathan S, DiazGranados CA. Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy. N Engl J Med. 2018;379(4):327-40. doi: 10.1056/NEJMoa1800820.